diff --git a/src/main/java/io/jboot/db/model/Columns.java b/src/main/java/io/jboot/db/model/Columns.java
index 2fc526af1b83a9f952c08edf6a18be0c47317f81..80a111b7a273ea493fa24fdcd2ae3541ebca7ac0 100644
--- a/src/main/java/io/jboot/db/model/Columns.java
+++ b/src/main/java/io/jboot/db/model/Columns.java
@@ -299,6 +299,7 @@ public class Columns implements Serializable {
      * @return
      */
     public Columns in(String name, List list) {
+        Util.checkNullParas(this, list);
         if (list != null && !list.isEmpty()) {
             in(name, list.toArray());
         }
@@ -326,6 +327,7 @@ public class Columns implements Serializable {
      * @return
      */
     public Columns notIn(String name, List list) {
+        Util.checkNullParas(this, list);
         if (list != null && !list.isEmpty()) {
             notIn(name, list.toArray());
         }
diff --git a/src/main/java/io/jboot/db/model/Util.java b/src/main/java/io/jboot/db/model/Util.java
index 665dafa3cc12a1ddfb0a57ae25131b4f4c1cd39d..75bee405a2fc92ee4d22ea7949ef7270d03aaed9 100644
--- a/src/main/java/io/jboot/db/model/Util.java
+++ b/src/main/java/io/jboot/db/model/Util.java
@@ -17,6 +17,7 @@ package io.jboot.db.model;
 
 
 import com.jfinal.ext.kit.DateKit;
+import io.jboot.utils.CollectionUtil;
 import io.jboot.utils.StrUtil;
 
 import java.util.*;
@@ -168,4 +169,12 @@ class Util {
             }
         }
     }
+
+    static void checkNullParas(Columns columns, List list) {
+        if (columns.isUseSafeMode()) {
+            if (CollectionUtil.isEmpty(list)) {
+                throw new NullPointerException("Columns must has not empty collection in safeMode.");
+            }
+        }
+    }
 }
diff --git a/src/main/java/io/jboot/utils/CollectionUtil.java b/src/main/java/io/jboot/utils/CollectionUtil.java
index 459eb2bfe289d608edcff040d52f105c974762aa..0e614b678513033479246dc3b8199126b8085492 100644
--- a/src/main/java/io/jboot/utils/CollectionUtil.java
+++ b/src/main/java/io/jboot/utils/CollectionUtil.java
@@ -15,6 +15,7 @@
  */
 package io.jboot.utils;
 
+import java.util.Collection;
 import java.util.HashMap;
 import java.util.Map;
 
@@ -37,4 +38,8 @@ public class CollectionUtil {
         }
         return map;
     }
+
+    public static boolean isEmpty(Collection collection){
+        return collection == null || collection.isEmpty();
+    }
 }